Peptide mimics of a major lupus epitope of SmB/B'. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Peptide mimics of a major lupus epitope of SmB/B'.

Dataset

identifier:	1696792
description:	epitope description:PPPGMRPP antigen name:Small nuclear ribonucleoprotein-associated proteins B and B' host organism:Homo sapiens Black antibody name:anti-PPPGMRPP
aggregation:	instance of dataset
availability:	available
primaryPublications:	12727642

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1004628
landingPage:	http://www.iedb.org/assay/1696792

Publication

type:	Literature
publicationVenue:	Ann N Y Acad Sci
dates:	2003

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Kenneth M Kaufman Monica Y Kirby John B Harley Judith A James

Data Type

method:	antigen inhibition

Study

name:	Peptide mimics of a major lupus epitope of SmB/B'.
description:	Epitope affinity-purified autoantibodies from a lupus patient reacted with the epitope in Western and dot blots. The epitope-MAP inhibited the epitope-specific Ab from binding to 5 of 6 phage-displayed random peptides selected with the Ab. It did not inhibit binding to phage clone expressing peptide SPLSTLL, which bound with low affinity in dot blots. The phage displayed epitope was constructed with an N-terminal Gly residue.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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