Human anti-Ro autoantibodies bind peptides accessible to the surface of the native Ro autoantigen.

Title:

Human anti-Ro autoantibodies bind peptides accessible to the surface of the native Ro autoantigen.

identifier:	1698843
description:	epitope description:TYYIKEQKLGL antigen name:60 kDa SS-A/Ro ribonucleoprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	7532872

study type:	b cell assays
subject species:	Homo sapiens

fullName:	S C Huang H Yu R H Scofield J B Harley

method:	ELISA

name:	Human anti-Ro autoantibodies bind peptides accessible to the surface of the native Ro autoantigen.
description:	The epitope sequence was previously described in Deutscher et al, Proc Natl Acad Sci USA:85(9479) 1988 [PMID:3200833]. The epitope sequence was deduced from a series of overlapping peptides. Binding to the epitope was significantly higher in sera from patients with SLE compared to healthy controls. Binding increased after sera were affinity purified with Ro protein.

name:	iedb
homePage:	http://www.iedb.org

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