Epitope mapping and serodiagnosis using Ata- and (Lys)7 peptides. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Epitope mapping and serodiagnosis using Ata- and (Lys)7 peptides.

Dataset

identifier:	1699810
description:	epitope description:DTPILPQ antigen name:Choriogonadotropin subunit beta host organism:Mus musculus BALB/c antibody name:OT-1A
aggregation:	instance of dataset
availability:	available
primaryPublications:	9528663

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1018132
landingPage:	http://www.iedb.org/assay/1699810

Publication

type:	Literature
publicationVenue:	Biochim Biophys Acta
dates:	1998

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	E E Loomans L J Nijholt A J Cremers W P Paulij W J Schielen

Data Type

method:	ELISA

Study

name:	Epitope mapping and serodiagnosis using Ata- and (Lys)7 peptides.
description:	Single alanine substitutions were performed to determine the essential residues. Substitution of Asp or Ile at positions 1 and 4, respectively, with Ala abolished binding, indicating these are essential residues. Substitution of Pro at position 6 reduced binding to the peptide-BSA conjugate but did not affect binding to the peptide N-terminally extended with an acetyl-thio-acetyl group, indicating that this residue is probably not essential.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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