Amino acid residues within the sequence region alpha 55-74 of Torpedo nicotinic acetylcholine receptor interacting with antibodies to the main immunogenic region and with snake alpha-neurotoxins.

Title:

Amino acid residues within the sequence region alpha 55-74 of Torpedo nicotinic acetylcholine receptor interacting with antibodies to the main immunogenic region and with snake alpha-neurotoxins.

Dataset

identifier:	1701044
description:	epitope description:RLRQQWIDVRLRWNPADYGG antigen name:Acetylcholine receptor subunit alpha host organism:Rattus norvegicus Lewis antibody name:mAb 198
aggregation:	instance of dataset
availability:	available
primaryPublications:	8510074

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1016958
landingPage:	http://www.iedb.org/assay/1701044

Publication

type:	Literature
publicationVenue:	J Recept Res
dates:	1993

Dimension

study type:	b cell assays
subject species:	Tetronarce californica

Person

fullName:	J L Wahlsten J M Lindstrom B M Conti-Tronconi

Data Type

method:	radio immuno assay (RIA)

Study

name:	Amino acid residues within the sequence region alpha 55-74 of Torpedo nicotinic acetylcholine receptor interacting with antibodies to the main immunogenic region and with snake alpha-neurotoxins.
description:	Mutational analysis revealed that residues W6, N14, and D17 were critical for binding in high and low ionic environments. Substitution of P15, A16, and Y18 were not tolerated in high ionic environments only. The mAb specific to human AChR cross-reacted with the epitope.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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