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identifier: 1701038
description:
epitope description:KHPEVKSAIEGIKYI
antigen name:Acetylcholine receptor subunit alpha (UniProt:P02708)
host organism:Rattus norvegicus Lewis
antibody name:155
aggregation:
instance of dataset
availability:
available
primaryPublications: 1374594
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1016974
landingPage: http://www.iedb.org/assay/1701038
type:
Literature
publicationVenue:
Am J Pathol
dates:
1992
study type: b cell assays
subject species: Homo sapiens
fullName:
M Osborn
A Marx
T Kirchner
S J Tzartos
U Plessman
K Weber
method:
western blot
name:
A shared epitope in the acetylcholine receptor-alpha subunit and fast troponin I of skeletal muscle. Is it important for myasthenia gravis?
description:
The epitope specific mAb 155 cross-reacted with 23 kDa cow troponin I. Cow fast troponin I contains residues 165-174 (EEKSGMEGRK) homologous to the epitope. MAb 155 decorates cow skeletal muscle myofibrils in a striated manner. It did not react with cardiac muscle.

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