The major neutralizing antibody responses to recombinant anthrax lethal and edema factors are directed to non-cross-reactive epitopes.

Title:

The major neutralizing antibody responses to recombinant anthrax lethal and edema factors are directed to non-cross-reactive epitopes.

identifier:	1701747
description:	epitope description:IPKDVLEIYS antigen name:Calmodulin-sensitive adenylate cyclase host organism:Mus musculus A/J
aggregation:	instance of dataset
availability:	available
primaryPublications:	19720758

study type:	b cell assays
subject species:	Bacillus anthracis

fullName:	Melissa L Nguyen Simon Terzyan Jimmy D Ballard Judith A James A Darise Farris

method:	ELISA

name:	The major neutralizing antibody responses to recombinant anthrax lethal and edema factors are directed to non-cross-reactive epitopes.
description:	This peptide is located at the PA binding domain of EF. This peptide and adjacent peptides spanning EF residues 87�102 conform an epitope region detected as reactive in 3 out of 3 independent immunization and mapping experiments. This peptide region is also reactive with the sera fraction enriched on Lethal factor reactivity, implying its recognition is by antibodies cross-reactive with LF. However, this cross-reactive fraction of EF antisera is unable to neutralize either EF or LF.

name:	iedb
homePage:	http://www.iedb.org

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