Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1016918 |
| landingPage: |
http://www.iedb.org/assay/1704729 |
| type: |
Literature
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| publicationVenue: |
Clin Exp Immunol
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| dates: |
1999
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| study type: | b cell assays |
| subject species: | Tetronarce californica |
| fullName: |
S J Tzartos
M Remoundos
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| method: |
cross blocking
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| name: |
Detection of antibodies directed against the cytoplasmic region of the human acetylcholine receptor in sera from myasthenia gravis patients.
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| description: |
The epitope sequence is found in the cited reference, Tzartos and Remoundos, Eur J Biochem. 207(3):915 [PMID: 1379917]. It has a single substitution in the human AChR protein, V to I at position 7.
The polyclonal papain-treated patients' sera was demonstrated to be epitope specific by its inhibition of binding to human AchR protein of the epitope-specific mAb. Approximately half of the sera (46/95) caused a detectable reduction (~20%) in the binding of epitope-specific MoAb 155, while efficient competition (≥50%) was seen with 16 sera (17%).
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
