Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1013023 |
| landingPage: |
http://www.iedb.org/assay/1702298 |
| type: |
Literature
|
| publicationVenue: |
Nat Struct Mol Biol
|
| dates: |
2008
|
| study type: | b cell assays |
| subject species: | Dengue virus 2 Thailand/16681/84 |
| fullName: |
Shee-Mei Lok
Victor Kostyuchenko
Grant E Nybakken
Heather A Holdaway
Anthony J Battisti
Soila Sukupolvi-Petty
Dagmar Sedlak
Daved H Fremont
Paul R Chipman
John T Roehrig
Michael S Diamond
Richard J Kuhn
Michael G Rossmann
|
| method: |
electron microscopy
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| name: |
Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins.
|
| description: |
The cryoEM reconstruction of Fab complexed with DENV2 incubated at 37 °C was determined to 24 Å resolution. An asymmetric unit contains two complexes of Fab and E protein and one uncomplexed E protein. The epitope on the domain III is completely exposed and its associated domain II has a fusion tip pointing toward the viral lipid envelope. The structure contains coordinates of only Calpha atoms, therefore the contacts cannot be calculated.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |