A 17-Mer self-peptide of acetylcholine receptor binds to B cell MHC class II, activates helper T cells, and stimulates autoantibody production and electrophysiologic signs of myasthenia gravis.

Title:

A 17-Mer self-peptide of acetylcholine receptor binds to B cell MHC class II, activates helper T cells, and stimulates autoantibody production and electrophysiologic signs of myasthenia gravis.

Dataset

identifier:	1704087
description:	epitope description:KSYCEIIVTHFPFDEQNCSMKLG antigen name:Acetylcholine receptor subunit alpha (UniProt:P02708) host organism:Rattus norvegicus Lewis
aggregation:	instance of dataset
availability:	available
primaryPublications:	9233656

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1016930
landingPage:	http://www.iedb.org/assay/1704087

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1997

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	H Yoshikawa E H Lambert D R Walser-Kuntz Y Yasukawa D J McCormick V A Lennon

Data Type

method:	in vivo assay

Study

name:	A 17-Mer self-peptide of acetylcholine receptor binds to B cell MHC class II, activates helper T cells, and stimulates autoantibody production and electrophysiologic signs of myasthenia gravis.
description:	Experimental autoimmune myashenia gravis (EAMG) was induced in three of twenty three rats by injection with the epitope.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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