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Title: Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.
identifier: 1704157
description:
epitope description:LEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSS
antigen name:E3 ubiquitin-protein ligase TRIM21
host organism:Rattus norvegicus DA
aggregation:
instance of dataset
availability:
available
primaryPublications: 15630133
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1016171
landingPage: http://www.iedb.org/assay/1704157
type:
Literature
publicationVenue:
J Exp Med
dates:
2005
study type: b cell assays
subject species: Homo sapiens
fullName:
Stina Salomonsson
Sven-Erik Sonesson
Lars Ottosson
Saad Muhallab
Tomas Olsson
Maria Sunnerhagen
Vijay K Kuchroo
Peter Thoré
n
Eric Herlenius
Marie Wahren-Herlenius
method:
immuno staining
name:
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.
description:
The anti-epitope sera stains cardiomyocytes in primary rat cardiomyocyte cultures and induce dysregulation of calcium homeostasis.

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