Structure of epitopes recognized by the antibodies to alpha(181-192) peptides of neuronal nicotinic acetylcholine receptors: extrapolation to the structure of acetylcholine-binding domain.

Title:

Structure of epitopes recognized by the antibodies to alpha(181-192) peptides of neuronal nicotinic acetylcholine receptors: extrapolation to the structure of acetylcholine-binding domain.

Dataset

identifier:	1705154
description:	epitope description:APGYKHEIKYNC antigen name:Neuronal acetylcholine receptor subunit alpha-3 host organism:Mus musculus BALB/c antibody name:1D6
aggregation:	instance of dataset
availability:	available
primaryPublications:	11730940

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1016904
landingPage:	http://www.iedb.org/assay/1705154

Publication

type:	Literature
publicationVenue:	J Neuroimmunol
dates:	2001

Dimension

study type:	b cell assays
subject species:	Rattus norvegicus

Person

fullName:	M Skok E Lykhmus S Bobrovnik S Tzartos T Tsouloufis R Vanderesse F Coutrot M Thong Cung M Marraud D Krikorian M Sakarellos-Daitsiotis

Data Type

method:	nuclear magnetic resonance (NMR)

Study

name:	Structure of epitopes recognized by the antibodies to alpha(181-192) peptides of neuronal nicotinic acetylcholine receptors: extrapolation to the structure of acetylcholine-binding domain.
description:	Analysis by 2D NMR of the epitope analog (with a Cys to Ala substitution at position 12) bound to epitope-specific mAb 1D6 showed that residues 6-11 had the greatest contributions to binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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