The binding of lupus-derived autoantibodies to the C-terminal peptide (83-119) of the major SmD1 autoantigen can be mediated by double-stranded DNA and nucleosomes.

Title:

The binding of lupus-derived autoantibodies to the C-terminal peptide (83-119) of the major SmD1 autoantigen can be mediated by double-stranded DNA and nucleosomes.

Dataset

identifier:	1705361
description:	epitope description:VEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR antigen name:Small nuclear ribonucleoprotein Sm D1 host organism:Mus musculus NZB X NZW antibody name:#36, #42, #56
aggregation:	instance of dataset
availability:	available
primaryPublications:	16540553

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1016149
landingPage:	http://www.iedb.org/assay/1705361

Publication

type:	Literature
publicationVenue:	Ann Rheum Dis
dates:	2006

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	J W Dieker C C Van Bavel G Riemekasten J H Berden J van der Vlag

Data Type

method:	ELISA

Study

name:	The binding of lupus-derived autoantibodies to the C-terminal peptide (83-119) of the major SmD1 autoantigen can be mediated by double-stranded DNA and nucleosomes.
description:	The epitope sequence was cited in Riemekasten et al. J Clin Invest. 1998 Aug 15 102(4):754-63 [PMID: 9710444]. The monoclonal anti-dsDNA antibodies did not recognize the antigen.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.