Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1706907 |
| description: |
epitope description:K501, S503, Y504, I505, R506, T507, S508, L513, R515, E517, N574, H575, L579
antigen name:Insulin receptor
host organism:Mus musculus BALB/c
antibody name:anti-insulin receptor monoclonal antibody 83-14
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
16957736 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1002493 |
| landingPage: |
http://www.iedb.org/assay/1706907 |
| type: |
Literature
|
| publicationVenue: |
Nature
|
| dates: |
2006
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Neil M McKern
Michael C Lawrence
Victor A Streltsov
Mei-Zhen Lou
Timothy E Adams
George O Lovrecz
Thomas C Elleman
Kim M Richards
John D Bentley
Patricia A Pilling
Peter A Hoyne
Kellie A Cartledge
Tam M Pham
Jennifer L Lewis
Sonia E Sankovich
Violet Stoichevska
Elizabeth Da Silva
Christine P Robinson
Maurice J Frenkel
Lindsay G Sparrow
Ross T Fernley
V Chandana Epa
Colin W Ward
|
| method: |
x-ray crystallography
|
| name: |
Structure of the insulin receptor ectodomain reveals a folded-over conformation.
|
| description: |
Epitope residues were defined based on calculating atom-atom contacts at distance of 4 Å
in the structure [PDB: 2DTG], chains C, D, E.
The crystal structure of the insulin receptor (IR-A) ectodomain dimer complexed with four Fabs from mAbs 83-7 and 83-14 was determined. Fab 83-14 interacts with FnIII domains of one monomer of the antigen homodimer.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
