Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry.

Title:

Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry.

Dataset

identifier:	1706967
description:	epitope description:ARGLT antigen name:Collagen alpha-1(II) chain host organism:Mus musculus DBA/1 antibody name:Mab CII-C1, CB268
aggregation:	instance of dataset
availability:	available
primaryPublications:	15163538

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1014605
landingPage:	http://www.iedb.org/assay/1706967

Publication

type:	Literature
publicationVenue:	Mol Immunol
dates:	2004

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Yuekang Xu Paul A Ramsland Janet M Davies Marita Scealy Kutty Selva Nandakumar Rikard Holmdahl Merrill J Rowley

Data Type

method:	ELISA

Study

name:	Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry.
description:	The epitope sequence was conserved in homo sapiens, mus musculus, rattus norvegicus, bos taurus, gallus gallus, porcine and mycobacterium tuberculosis C. The epitope specific mAbs CII-C1 (IgG2a) and CB268 (IgG1) reacted strongly with native bovine CII with similar titration profiles.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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