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Title: Myasthenia gravis: effect on antibody binding of conservative substitutions of amino acid residues forming the main immunogenic region of the nicotinic acetylcholine receptor.
identifier: 1707464
description:
epitope description:WNPADYGGIKWNPADYGGIK
host organism:Rattus norvegicus Lewis
antibody name:6
aggregation:
instance of dataset
availability:
available
primaryPublications: 8463998
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1016961
landingPage: http://www.iedb.org/assay/1707464
type:
Literature
publicationVenue:
J Recept Res
dates:
1993
study type: b cell assays
subject species:
fullName:
J L Wahlsten
J M Lindstrom
N Ostlie
X D Wu
B M Conti-Tronconi
method:
radio immuno assay (RIA)
name:
Myasthenia gravis: effect on antibody binding of conservative substitutions of amino acid residues forming the main immunogenic region of the nicotinic acetylcholine receptor.
description:
The epitope is a 2x repeat of a naturally occurring epitope.
At high ionic conditions, residues N2, D5, Y6, N12, D15, and Y16 were critical for binding. Mutation of D5 and D15 to E or N residues increased binding of mAbs 22 and 28.

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