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Title: Main immunogenic region of Torpedo electroplax and human muscle acetylcholine receptor: localization and microheterogeneity revealed by the use of synthetic peptides.
identifier: 1708512
description:
epitope description:SAIEGVKYIAEHMKSDEESSN
antigen name:Acetylcholine receptor subunit alpha
host organism:Rattus norvegicus Lewis
antibody name:153, 155, 164
aggregation:
instance of dataset
availability:
available
primaryPublications: 1688377
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1017016
landingPage: http://www.iedb.org/assay/1708512
type:
Literature
publicationVenue:
J Neurochem
dates:
1990
study type: b cell assays
subject species: Tetronarce californica
fullName:
S J Tzartos
H V Loutrari
F
A Kokla
S L Walgrave
R P Milius
B M Conti-Tronconi
method:
antigen inhibition
name:
Main immunogenic region of Torpedo electroplax and human muscle acetylcholine receptor: localization and microheterogeneity revealed by the use of synthetic peptides.
description:
The epitope sequence is from the reference cited: Ratnam et al. (1986) Biochemistry 25: 2633-2643 [PMID: 3718969].
The epitope inhibited the binding of the mAbs to intact Torpedo AChR. The overlapping peptide 360-378 also inhibited binding. The authors conclude that the mAbs bind in the region 372-380. The mAbs did not bind any peptides in a study of overlapping peptides spanning the sequence of AChR alpha subunit.

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