Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.

Dataset

identifier:	1708125
description:	epitope description:CGADSYEMEEDGVRKC + OX(C1, C16) antigen name:Epidermal growth factor receptor host organism:Mus musculus BALB/c antibody name:mAb175
aggregation:	instance of dataset
availability:	available
primaryPublications:	19289842

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1018806
landingPage:	http://www.iedb.org/assay/1708125

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2009

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Thomas P J Garrett Antony W Burgess Hui K Gan Rod B Luwor Glenn Cartwright Francesca Walker Suzanne G Orchard Andrew H A Clayton Edouard C Nice Julie Rothacker Bruno Catimel Webster K Cavenee Lloyd J Old Elisabeth Stockert Gerd Ritter Timothy E Adams Peter A Hoyne Dane Wittrup Ginger Chao Jennifer R Cochran Cindy Luo Mezhen Lou Trevor Huyton Yibin Xu W Douglas Fairlie Shenggen Yao Andrew M Scott Terrance G Johns

Data Type

method:	x-ray crystallography

Study

name:	Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.
description:	The epitope has a disulfide bond between cysteine residues at positions 1 and 16. In the structure, the conformation of the epitope backbone between amino acids 293 and 302 was essentially identical in complexes with both Fabs, mAb806 [PDB: 1G5V] and mAb175 (this structure) and closely related to the conformation of this region in the whole EGFR structure [PDB: 1MOX]. In contrast, the free peptide adopts a random coil structure, as determined by NMR spectroscopy (this reference).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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