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Title: Main immunogenic region of Torpedo electroplax and human muscle acetylcholine receptor: localization and microheterogeneity revealed by the use of synthetic peptides.
identifier: 1708351
description:
epitope description:IDISDISGKQVTGEVIFQT
antigen name:Acetylcholine receptor subunit alpha
host organism:Rattus norvegicus Lewis
antibody name:5, 19, 142
aggregation:
instance of dataset
availability:
available
primaryPublications: 1688377
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1017016
landingPage: http://www.iedb.org/assay/1708351
type:
Literature
publicationVenue:
J Neurochem
dates:
1990
study type: b cell assays
subject species: Tetronarce californica
fullName:
S J Tzartos
H V Loutrari
F
A Kokla
S L Walgrave
R P Milius
B M Conti-Tronconi
method:
radio immuno assay (RIA)
name:
Main immunogenic region of Torpedo electroplax and human muscle acetylcholine receptor: localization and microheterogeneity revealed by the use of synthetic peptides.
description:
The epitope sequence is from the reference cited: Ratnam et al. (1986) Biochemistry 25: 2633-2643 [PMID: 3718969].
The mAbs 5 and 142 bound to the epitope in a study of overlapping peptides spanning the sequence of AChR alpha subunit. MAb 19 bound weakly to the epitope and more weakly to other peptides throughout the sequence. The epitope inhibited the binding of mAb 19 to intact Torpedo AChR.

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