Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1017016 |
| landingPage: |
http://www.iedb.org/assay/1711991 |
| type: |
Literature
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| publicationVenue: |
J Neurochem
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| dates: |
1990
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| study type: | b cell assays |
| subject species: | Tetronarce californica |
| fullName: |
S J Tzartos
H V Loutrari
F
A Kokla
S L Walgrave
R P Milius
B M Conti-Tronconi
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| method: |
radio immuno assay (RIA)
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| name: |
Main immunogenic region of Torpedo electroplax and human muscle acetylcholine receptor: localization and microheterogeneity revealed by the use of synthetic peptides.
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| description: |
The epitope sequence is from the reference cited: Barkas et al. (1988) J Biol Chem 263: 5916-5920 [PMID: 2451673].
The epitope recognized by the mAbs was determined by its reactivity with overlapping peptides spanning the sequence of AChR. The mAbs recognized a tandem repeat of the epitope. The tandem epitope repeat peptide inhibited the binding of mAb 198 or 203 to alpha-bungarotoxin-labeled native Torpedo AChR as well as a tandem repeat of the homologous human AChR alpha peptide 67-76. The authors conclude that mAbs 198 and 203 recognize residues 67-74 in the main immunogenic region (MIR).
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
