Superiority of thyroid peroxidase DNA over protein immunization in replicating human thyroid autoimmunity in HLA-DRB1*0301 (DR3) transgenic mice.

Title:

Superiority of thyroid peroxidase DNA over protein immunization in replicating human thyroid autoimmunity in HLA-DRB1*0301 (DR3) transgenic mice.

identifier:	1709695
description:	epitope description:GLPRLETPADLSTAIASRS antigen name:Thyroid peroxidase (UniProt:P07202) host organism:Mus musculus NOD HLA-DR3 Tg IAbeta null
aggregation:	instance of dataset
availability:	available
primaryPublications:	15320899

study type:	b cell assays
subject species:	Homo sapiens

fullName:	J C Flynn A Gardas Q Wan M Gora G Alsharabi W Z Wei A A Giraldo C S David Y M Kong J P Banga

method:	cross blocking

name:	Superiority of thyroid peroxidase DNA over protein immunization in replicating human thyroid autoimmunity in HLA-DRB1*0301 (DR3) transgenic mice.
description:	The epitope sequence is from the reference cited: Hobby et al.(2000) Endocrinology 141: 2018-2026 [PMID: 10830285]. The epitope was deduced. Rabbit anti-epitope (p14) antiserum competed serum from hTPO immunized mice from binding to TPO, indicating the mouse sera contained antibodies to the epitope. The epitope defines the immunodominant region-B on TPO (following the nomenclature used with mouse mAbs to TPO). Sera from both DR3 NOD and C57BL/6 X CBA)F1 had antibodies to the epitope. Thyroiditis was observed in 3 of 13 DR3 NOD mice immunized with TPO and GM-CSF (or IL-12).

name:	iedb
homePage:	http://www.iedb.org

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