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Title: Identification of an immunodominant region recognized by human autoantibodies in a three-dimensional model of thyroid peroxidase.
identifier: 1709808
description:
epitope description:LQVQDQLMNEELTER
antigen name:Thyroid peroxidase (UniProt:P07202)
host organism:Oryctolagus cuniculus New Zealand White
aggregation:
instance of dataset
availability:
available
primaryPublications: 10830285
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1017368
landingPage: http://www.iedb.org/assay/1709808
type:
Literature
publicationVenue:
Endocrinology
dates:
2000
study type: b cell assays
subject species: Homo sapiens
fullName:
P Hobby
A Gardas
R Radomski
A M McGregor
J P Banga
B J Sutton
method:
antigen inhibition
name:
Identification of an immunodominant region recognized by human autoantibodies in a three-dimensional model of thyroid peroxidase.
description:
Native soluble human thyroid peroxidase partially inhibited rabbit anti-epitope sera binding to TPO coated on ELISA plates. This was unexpected as the epitope was predicted to be buried in the native TPO molecule.The rabbit anti-epitope sera reacted with human thyroid peroxidase (TPO) by ELISA and RIA.

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