Determination at the molecular level of a B-cell epitope on thyroid peroxidase likely to be associated with autoimmune thyroid disease.

Title:

Determination at the molecular level of a B-cell epitope on thyroid peroxidase likely to be associated with autoimmune thyroid disease.

identifier:	1711283
description:	epitope description:KFPEDFESC antigen name:Thyroid peroxidase (UniProt:P07202) host organism:Mus musculus BALB/c antibody name:47
aggregation:	instance of dataset
availability:	available
primaryPublications:	1716262

study type:	b cell assays
subject species:	Homo sapiens

fullName:	R Finke P Seto J Ruf P Carayon B Rapoport

method:	western blot

name:	Determination at the molecular level of a B-cell epitope on thyroid peroxidase likely to be associated with autoimmune thyroid disease.
description:	The epitope was deduced. The epitope was deduced based on reactivity with protein fragments expressed by a TPO random 66-166 fragment cDNA library. The epitope was the minimal region common to all positive fragments. Epitope-specific mAb 47 reacted with denatured and reduced TPO protein by Western blotting and immunoprecipitated nondenatured TPO.

name:	iedb
homePage:	http://www.iedb.org

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