Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic.

Title:

Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic.

Dataset

identifier:	1714937
description:	epitope description:RDSEGDLVAEKLGPI antigen name:Beta-galactosidase host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	16025495

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017208
landingPage:	http://www.iedb.org/assay/1714937

Publication

type:	Literature
publicationVenue:	Hepatology
dates:	2005

Dimension

study type:	b cell assays
subject species:	Lactobacillus delbrueckii subsp. bulgaricus

Person

fullName:	Dimitrios-Petrou Bogdanos Harold Baum Manabu Okamoto Paolo Montalto Umesh C Sharma Eirini I Rigopoulou John Vlachogiannakos Yun Ma Andrew K Burroughs Diego Vergani

Data Type

method:	antigen inhibition

Study

name:	Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic.
description:	The epitope inhibited the binding of PBC sera to the epitope and to PDC-E2_212-226 peptide (KLSEGDLLAEIETDK). The epitope also inhibited the binding of PBC sera to the PDC protein as epitope-preincubated sera did not reduce PDC enzymatic activity.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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