Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity.

Title:

Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity.

identifier:	1713276
description:	epitope description:I66, E67, Y88, I91, E113, R115, F136, G138, F140, E163, K189 antigen name:Thyrotropin receptor host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	15319453

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Sabine Costagliola Marco Bonomi Nils G Morgenthaler Joost Van Durme Valé rie Panneels Samuel Refetoff Gilbert Vassart

method:	cross blocking

name:	Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity.
description:	MAb IRI-SAB3, which recognizes the epitopic residues, competed the binding to TSHR by sera from Graves' disease patients. Binding to TSHR by sera from 8 patients scoring positive in a TSH-blocking antibody assay was also competed by mAb IRI-SAb3. Sera from controls or from Hashimoto's patients without TSH-blocking antibody were not competed.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.