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Title: Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis*.
identifier: 1713517
description:
epitope description:GLPRLETPADLSTAIASRS
antigen name:Thyroid peroxidase (UniProt:P07202)
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 18363888
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1013128
landingPage: http://www.iedb.org/assay/1713517
type:
Literature
publicationVenue:
Clin Endocrinol (Oxf)
dates:
2008
study type: b cell assays
subject species: Homo sapiens
fullName:
Claus H Nielsen
Thomas H Brix
Andrzej Gardas
J Paul Banga
Laszlo Hegedü
s
method:
cross blocking
name:
Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis*.
description:
The epitope sequence is from the reference cited: Hobby et al. (2000) Endocrinology 141: 2018-2026 [PMID: 10830285].
Rabbit anti-epitope antibody (anti-P14) competed sera from patients with Hashimoto's thyroiditis from binding to human TPO in a competitive ELISA. The anti-P14 antibody is used to define immunodominant region B (IDR-B). The percentage of antibodies to IDR-B was significantly lower in sera of the HT group (50 +/- 15%) compared to the healthy control group (66 +/- 22%). A slight decrease in IDR-B reactivity with increasing TPO antibody level was observed. IDR-B reactivity was not dependent on patient age.

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