Identification of an important thyrotrophin binding site on the human thyrotrophin receptor using monoclonal antibodies.

Title:

Identification of an important thyrotrophin binding site on the human thyrotrophin receptor using monoclonal antibodies.

identifier:	1713656
description:	epitope description:GYKEKSKFQD antigen name:Thyrotropin receptor host organism:Mus musculus BALB/c antibody name:3B12
aggregation:	instance of dataset
availability:	available
primaryPublications:	10375031

study type:	b cell assays
subject species:	Homo sapiens

fullName:	P S Shepherd C R Da Costa J C Cridland K S Gilmore A P Johnstone

method:	western blot

name:	Identification of an important thyrotrophin binding site on the human thyrotrophin receptor using monoclonal antibodies.
description:	The epitope was deduced. The epitope recognized by mAb 3B12 was deduced based on reactivity with overlapping 8-mer peptides. Further analysis with overlapping 4-mer, 5-mer and 6-mer peptides showed the minimal epitope was YKEKSK, but the addition of Phe at the C-terminus increased reactivity.

name:	iedb
homePage:	http://www.iedb.org

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