Dual mechanism of perturbation of thyrotropin-mediated activation of thyroid cells by antibodies to the thyrotropin receptor (TSHR) and TSHR-derived peptides.

Title:

Dual mechanism of perturbation of thyrotropin-mediated activation of thyroid cells by antibodies to the thyrotropin receptor (TSHR) and TSHR-derived peptides.

Dataset

identifier:	1760953
description:	epitope description:NALNSPLHQEYEENL antigen name:Thyrotropin receptor host organism:Oryctolagus cuniculus New Zealand White
aggregation:	instance of dataset
availability:	available
primaryPublications:	8103771

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017412
landingPage:	http://www.iedb.org/assay/1760953

Publication

type:	Literature
publicationVenue:	J Clin Endocrinol Metab
dates:	1993

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	R K Desai J S Dallas M K Gupta G S Seetharamaiah J L Fan K L D Kohn B S Prabhakar

Data Type

method:	biological activity

Study

name:	Dual mechanism of perturbation of thyrotropin-mediated activation of thyroid cells by antibodies to the thyrotropin receptor (TSHR) and TSHR-derived peptides.
description:	The epitope sequence was cited in Nagayama et al. Biochem Biophys Res Commun. 1989 Dec 29 165(3):1184-90 [PMID: 2558651]. The ability of the epitope-specific antibodies to block TSH mediated stimulation of 125I uptake by rat thyroid cells was measured.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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