Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence.

Title:

Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence.

Dataset

identifier:	1761278
description:	epitope description:ERPLELRVRVLDI antigen name:Desmoglein-1 host organism:Homo sapiens antibody name:3–30/3h
aggregation:	instance of dataset
availability:	available
primaryPublications:	19340014

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017657
landingPage:	http://www.iedb.org/assay/1761278

Publication

type:	Literature
publicationVenue:	J Invest Dermatol
dates:	2009

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Mariko Yokouchi Marwah Adly Saleh Keiko Kuroda Takahisa Hachiya John R Stanley Masayuki Amagai Ken Ishii

Data Type

method:	immunoprecipitation

Study

name:	Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence.
description:	The epitope sequence is found in the accession cited in Sekiguchi et al, J Immunol. 2001 167(9):5439 [PMID: 11673563]. The epitope for this pathogenic, conformation-dependent mAb was deduced using domain-swapped proteins where Dsg1 domains are individually expressed in the context of Dsg3 protein.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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