A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells.

Title:

A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells.

Dataset

identifier:	1717123
description:	epitope description:MIHFGND antigen name:Major prion protein host organism:Mus musculus PrP null antibody name:T1
aggregation:	instance of dataset
availability:	available
primaryPublications:	20377745

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019268
landingPage:	http://www.iedb.org/assay/1717123

Publication

type:	Literature
publicationVenue:	Microbiol Immunol
dates:	2010

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	Yoshihisa Shimizu Yuko Kaku-Ushiki Yoshifumi Iwamaru Tamaki Muramoto Tetsuyuki Kitamoto Takashi Yokoyama Shirou Mohri Yuichi Tagawa

Data Type

method:	biological activity

Study

name:	A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells.
description:	The epitope was deduced. The epitope specific monoclonal antibody failed to inhibit PrP^Sc accumulation in ScN2a cells.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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