Identification of a cross-reactive epitope widely present in lipopolysaccharide from enterobacteria and recognized by the cross-protective monoclonal antibody WN1 222-5.

Title:

Identification of a cross-reactive epitope widely present in lipopolysaccharide from enterobacteria and recognized by the cross-protective monoclonal antibody WN1 222-5.

Dataset

identifier:	1737047
description:	epitope description:alpha-D-Glcp-(1->3)-[L-alpha-D-Hepp-(1->7)]-L-alpha-D-Hepp-4P antigen name:lipopolysaccharide host organism:Mus musculus NZB antibody name:WN1 222-5
aggregation:	instance of dataset
availability:	available
primaryPublications:	12716894

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/797
landingPage:	http://www.iedb.org/assay/1737047

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2003

Dimension

study type:	b cell assays
subject species:	Enterobacteriaceae

Person

fullName:	Sven Muller-Loennies Lore Brade C Roger MacKenzie Franco E Di Padova Helmut Brade

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	Identification of a cross-reactive epitope widely present in lipopolysaccharide from enterobacteria and recognized by the cross-protective monoclonal antibody WN1 222-5.
description:	The epitope is defined at the junction of outer and inner core of LPS from enterobacteria, such as E. coli, S. enterica, and Shigella. Additional regions, such as lipid A backbone, the side chain Kdo, or both, are needed for the binding, but the lipids are not involved in the recognition. The kinetic constants of the free oligosaccharide OS1 of E. coli F653 R3 type LPS core region for binding to the epitope-specific mAb WN1 222-5 was determined by SPR.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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