Immune recognition of hormonogenic sites of human thyroglobulin: studies of Graves' sera and a murine monoclonal antibody with thyroid hormone antibody activity.

Title:

Immune recognition of hormonogenic sites of human thyroglobulin: studies of Graves' sera and a murine monoclonal antibody with thyroid hormone antibody activity.

Dataset

identifier:	1760630
description:	epitope description:HAPENYGHGSLE antigen name:Thyroglobulin host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	7522798

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017392
landingPage:	http://www.iedb.org/assay/1760630

Publication

type:	Literature
publicationVenue:	Endocr J
dates:	1993

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	S Sakata M Matsuda H I Matsui H Sarui H Maekawa K Okuda O Tarutani

Data Type

method:	antigen inhibition

Study

name:	Immune recognition of hormonogenic sites of human thyroglobulin: studies of Graves' sera and a murine monoclonal antibody with thyroid hormone antibody activity.
description:	The epitope sequence was cited in Malthié ry and Lissitzky Eur J Biochem. 1987 Jun 15 165(3):491-8 [PMID: 3595599]. The epitope did not inhibit binding of the sera from Grave's patients to 125I-T4. Direct binding of the 125I-labeled epitope with gamma globulin in sera from Graves' patients was also negative. None of the patient sera showed significantly higher binding to the epitope than sera from healthy subjects.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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