Immunoadsorption against two distinct epitopes on human type XVII collagen abolishes dermal-epidermal separation induced in vitro by autoantibodies from pemphigoid gestationis patients.

Title:

Immunoadsorption against two distinct epitopes on human type XVII collagen abolishes dermal-epidermal separation induced in vitro by autoantibodies from pemphigoid gestationis patients.

Dataset

identifier:	1761715
description:	epitope description:RSILPYGDSMDRIE antigen name:Collagen alpha-1(XVII) chain host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	16552711

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017278
landingPage:	http://www.iedb.org/assay/1761715

Publication

type:	Literature
publicationVenue:	Eur J Immunol
dates:	2006

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Josep E Herrero-Gonzá lez Olaf Brauns Ralf Egner Wolfgang Rö nspeck José M Mascaró Jr Marcel F Jonkman Detlef Zillikens Cassian Sitaru

Data Type

method:	biological activity

Study

name:	Immunoadsorption against two distinct epitopes on human type XVII collagen abolishes dermal-epidermal separation induced in vitro by autoantibodies from pemphigoid gestationis patients.
description:	Epitope specific antibodies were isolated from pemphigoid gestationis patients and shown to cause dermal-epidermal separation in an in vitro model of skin criosection culture. The flow through fraction also caused the effect, implying antibodies specific for other epitopes are responsible for the effect as well .

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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