Two-dimensional NMR investigations of the interactions of antibodies with peptide antigens. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Two-dimensional NMR investigations of the interactions of antibodies with peptide antigens.

Dataset

identifier:	1764243
description:	epitope description:HIDSQKKA antigen name:Cholera enterotoxin subunit B host organism:Oryctolagus cuniculus antibody name:TE34
aggregation:	instance of dataset
availability:	available
primaryPublications:	8375614

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019255
landingPage:	http://www.iedb.org/assay/1764243

Publication

type:	Literature
publicationVenue:	FASEB J
dates:	1993

Dimension

study type:	b cell assays
subject species:	Vibrio cholerae

Person

fullName:	J Anglister B Zilber R Levy A Zvi R Hiller D Feigelson

Data Type

method:	nuclear magnetic resonance (NMR)

Study

name:	Two-dimensional NMR investigations of the interactions of antibodies with peptide antigens.
description:	NMR was used to discern the size and conformation of the epitope. Mono-specific antibodies (TE34) raised against the 15 residue peptide were characterized and found to be reactive with residues 8-15. Contact residues were identified as H8, I9, D10, K13, K14 and A15. The authors state that this antibody was not reactive with the whole cholera toxin (data not shown).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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