The cysteine-rich amino terminus of the thyrotropin receptor is the immunodominant linear antibody epitope in mice immunized using naked deoxyribonucleic acid or adenovirus vectors.

Title:

The cysteine-rich amino terminus of the thyrotropin receptor is the immunodominant linear antibody epitope in mice immunized using naked deoxyribonucleic acid or adenovirus vectors.

Dataset

identifier:	1764156
description:	epitope description:YVSIDVTLQQLESHSFYNLS antigen name:Thyrotropin receptor host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	12697676

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017359
landingPage:	http://www.iedb.org/assay/1764156

Publication

type:	Literature
publicationVenue:	Endocrinology
dates:	2003

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Lise Schwarz-Lauer Pavel N Pichurin Chun-Rong Chen Yuji Nagayama Charmaine Paras John C Morris Basil Rapoport Sandra M McLachlan

Data Type

method:	ELISA

Study

name:	The cysteine-rich amino terminus of the thyrotropin receptor is the immunodominant linear antibody epitope in mice immunized using naked deoxyribonucleic acid or adenovirus vectors.
description:	The epitope sequence is from the reference cited: Morris et al. (1993) J Biol Chem 268: 10900-10905 [PMID: 8496155]. Three of the four immunized mice developed hyperthyrodisim, as determined by T4 levels.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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