Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity.

Title:

Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity.

identifier:	2119621
description:	epitope description:[2)-beta-QuiN4Fm-(1->4)-alpha-GalNAcAN-(1->4)-alpha-GalNAcAN-(1->3)-beta-QuiNAc-(1->]n antigen name:lipopolysaccharide host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	25171003

type:	Literature
publicationVenue:	Monoclon Antib Immunodiagn Immunother
dates:	2014

study type:	b cell assays
subject species:	Francisella tularensis

fullName:	Zhaohua Lu Michael J Rynkiewicz Chiou-Ying Yang Guillermo Madico Hillary M Perkins Marly I Roche Barbara A Seaton Jacqueline Sharon

method:	in vivo assay

name:	Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity.
description:	Administration of the epitope-reactive mAb N203 in vivo reduced the blood bacterial burden after infection with Francisellla tularenis SchuS4 by 92%, as assessed 3 days post-infection and significantly prolonged survival compared to controls at 24 h.

name:	iedb
homePage:	http://www.iedb.org

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