How lamina-associated polypeptide 1 (LAP1) activates Torsin. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

How lamina-associated polypeptide 1 (LAP1) activates Torsin.

Dataset

identifier:	2119748
description:	epitope description:S405, Y493, D497, H498, E499, N500, D555, K556, S562, R563 antigen name:Torsin-1A-interacting protein 1 host organism:Vicugna pacos antibody name:VHH-BS1
aggregation:	instance of dataset
availability:	available
primaryPublications:	25149450

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1028149
landingPage:	http://www.iedb.org/assay/2119748

Publication

type:	Literature
publicationVenue:	Elife
dates:	2014

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Brian A Sosa F Esra Demircioglu James Z Chen Jessica Ingram Hidde L Ploegh Thomas U Schwartz

Data Type

method:	x-ray crystallography

Study

name:	How lamina-associated polypeptide 1 (LAP1) activates Torsin.
description:	The epitope residues were calculated from [PDB: 4TVS] as the antigen residues at 4Å atomic distance from the antibody. The epitope of VHH-BS1 on the luminal domain of lamina-associated polypeptide 1 (LAP1) was determined from the crystal structure of the complex, solved using molecular replacement. VHH-BS1 was used as a crystallization chaperone. There are two complexes of LAP1-VHH molecules in the asymmetric unit. VHH-BS1 binds to the area immediately surrounding the arginine finger of LAP1, thereby interfering with TorsinA binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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