Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice.

Title:

Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice.

Dataset

identifier:	2119809
description:	epitope description:GDQGVPGEAGAPGLVGPRGERGFP antigen name:Collagen alpha-1(II) chain host organism:Mus musculus BALB/c X B10.Q
aggregation:	instance of dataset
availability:	available
primaryPublications:	25005029

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1028159
landingPage:	http://www.iedb.org/assay/2119809

Publication

type:	Literature
publicationVenue:	Arthritis Res Ther
dates:	2014

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Ingrid Lindh Omri Snir Erik Lö nnblom Hü seyin Uysal Ida Andersson Kutty Selva Nandakumar Michel Vierboom Bert 't Hart Vivianne Malmströ m Rikard Holmdahl

Data Type

method:	ELISA

Study

name:	Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice.
description:	The epitope was recognized at the early-chronic phase (day 80) of the disease. The epitope was expressed with surrounding (GPP)5 sequences, an N-terminal His6-tag followed by a thrombin cleavage site (MGSSHHHHHHSSGLVPRGSHMG), and a foldon trimerization domain (SGYIPEAPRDGQAYVRKDGEWVLLSTFL) at the C-terminus.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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