Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1796479 |
| description: |
epitope description:E22, H23, E24, T25, R26, L27, V28, A29, K30, L31, F32, K33, D34, W80, V81, D82, Y83, N84, L85, K86, W87, N88, P89, D90, D91, Y92, G93, G94, V95, K96, K97, I98, H99, I100, P101
antigen name:Acetylcholine receptor subunit alpha (UniProt:P02708)
host organism:Rattus norvegicus Lewis
antibody name:mAb 198
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
19890000 |
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1017958 |
| landingPage: |
http://www.iedb.org/assay/1796479 |
| type: |
Literature
|
| publicationVenue: |
J Neurosci
|
| dates: |
2009
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| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Jie Luo
Palmer Taylor
Mario Losen
Marc H de Baets
G Diane Shelton
Jon Lindstrom
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| method: |
radio immuno assay (RIA)
|
| name: |
Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity.
|
| description: |
Sequences of the extracellular domain of human AChR alpha 7 subunits were replaced by homologous human alpha 1 sequences to determine which alpha 1 sequences would confer antigenicity of an alpha 1 immunogenic region to an alpha 1/alpha 7 chimera. These chimeric constructs were used to elucidate epitopic determinants for a set of monoclonal antibodies. Two discontinuous regions were defined for this mAb, which are adjacent only in the native conformation.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
