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Title: Mechanism of dinitrochlorobenzene-induced dermatitis in mice: role of specific antibodies in pathogenesis.
identifier: 1796481
description:
epitope description:2,4-dinitrophenyl group
host organism:Mus musculus BALB/c
aggregation:
instance of dataset
availability:
available
primaryPublications: 19890385
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1019848
landingPage: http://www.iedb.org/assay/1796481
type:
Literature
publicationVenue:
PLoS One
dates:
2009
study type: b cell assays
subject species:
fullName:
Elizabeth Yan Zhang
Aaron Yun Chen
Bao Ting Zhu
method:
ELISA
name:
Mechanism of dinitrochlorobenzene-induced dermatitis in mice: role of specific antibodies in pathogenesis.
description:
Topical administration of DNCB induced DNCB-specific Ab in mice by day 11 after 2 doses of DNCB. Administration of dexamethasone (DEX) reduced the level of anti-DNCB Ab. DNCB-specific serum IgG levels in the B-KO mice remained at the baseline levels following multiple DNCB treatments, which demonstrated that the B-KO mice could not produce DNCB-specific Abs. Serum IgG1, IgG2a, and IgG2b were all positive.

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