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Title: Immunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease.
identifier: 1796747
description:
epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
antigen name:Amyloid beta A4 protein
host organism:Mus musculus BALB/c
antibody name:P4D6
aggregation:
instance of dataset
availability:
available
primaryPublications: 20493257
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1020941
landingPage: http://www.iedb.org/assay/1796747
type:
Literature
publicationVenue:
Neurobiol Dis
dates:
2010
study type: b cell assays
subject species: Homo sapiens
fullName:
Chiou-Miin Wang
Sarah Devries
Marybeth Camboni
Matthew Glass
Paul T Martin
method:
biological activity
name:
Immunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease.
description:
Epitope-specific immune serum and epitope-specific mAb blocked amyloid aggregation of the epitope in aqueous solution. Pre-clearing of epitope-immune serm on Aß1-42 peptide removed its blocking ability.

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