Cardiolipin binding a light chain from lupus-prone mice. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Cardiolipin binding a light chain from lupus-prone mice.

Dataset

identifier:	1797411
description:	epitope description:cardiolipin host organism:Mus musculus NZW X BXSB antibody name:A1.84
aggregation:	instance of dataset
availability:	available
primaryPublications:	9477972

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1007316
landingPage:	http://www.iedb.org/assay/1797411

Publication

type:	Literature
publicationVenue:	Biochemistry
dates:	1998

Dimension

study type:	b cell assays
subject species:	Bos taurus

Person

fullName:	B Pereira C R Benedict A Le S S Shapiro P Thiagarajan

Data Type

method:	ELISA

Study

name:	Cardiolipin binding a light chain from lupus-prone mice.
description:	The dissociation constant of the light chain for cardiolipin was similar to the intact molecule. These studies demonstrate that the VL sequence alone, in the absence of any other immunoglobulin domains, can mediate cardiolipin binding, raising the possibility that antigen specificity of certain antibodies may exclusively reside in their light-chain sequences. The dissociation constants of recombinant scFv fragments were virtually identical: 21 nM for the light chain VL84 and 23 nM for scFv of A1.84.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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