Administration of GAS914 in an orthotopic pig-to-baboon heart transplantation model. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Administration of GAS914 in an orthotopic pig-to-baboon heart transplantation model.

Dataset

identifier:	1797312
description:	epitope description:alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group host organism:Papio
aggregation:	instance of dataset
availability:	available
primaryPublications:	15693844

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1020632
landingPage:	http://www.iedb.org/assay/1797312

Publication

type:	Literature
publicationVenue:	Xenotransplantation
dates:	2005

Dimension

study type:	b cell assays
subject species:	Sus scrofa

Person

fullName:	Ulrike Brandl Sebastian Michel Matthias Erhardt Paolo Brenner Iris Bittmann Matthias Rö ssle Heiko Baschnegger Andreas Bauer Claus Hammer Michael Schmoeckel Bruno Reichart

Data Type

method:	in vivo assay

Study

name:	Administration of GAS914 in an orthotopic pig-to-baboon heart transplantation model.
description:	The epitope caused an immediate and significant reduction of both anti-Galalpha(1,3)Gal IgM and IgG antibodies. However, sufficient antibody reduction was independent of dosage and form of application of GAS914. A pre-transplant GAS914 treatment was not necessary to effectively reduce antibody levels and prevent hyperacute rejection.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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