Naturally-occurring human serum antibodies to inner core lipopolysaccharide epitopes of Neisseria meningitidis protect against invasive meningococcal disease caused by isolates displaying homologous inner core structures.

Title:

Dataset

identifier:	1797770
description:	epitope description:D-Glcp-(1->3)-[alpha-D-GlcpNAc-(1->2)]-6-PEA-L-alpha-D-Hepp-(1->3)-L-alpha-D-Hepp-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo antigen name:lipooligosaccharide host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	18835574

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1014111
landingPage:	http://www.iedb.org/assay/1797770

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2008

Dimension

study type:	b cell assays
subject species:	Neisseria meningitidis MC58

Person

fullName:	Anne Jä kel Joyce S Plested J Claire Hoe Katherine Makepeace Margaret-Anne J Gidney Suzanne Lacelle Frank St Michael Andrew D Cox James C Richards E Richard Moxon

Data Type

method:	ELISA

Study

name:	Naturally-occurring human serum antibodies to inner core lipopolysaccharide epitopes of Neisseria meningitidis protect against invasive meningococcal disease caused by isolates displaying homologous inner core structures.
description:	The epitope is the inner core region of LOS from N. meningitidis MC58 and other strains. The epitope-specific IgG preparation reacts with LOS from WT (MC58 strain) and with mutants that lack the outer core region and/or the PEtn residue at position 3 of HepII in ELISA.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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