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Title: Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.
identifier: 1797749
description:
epitope description:DAEFRHDSGYE
antigen name:Amyloid beta A4 protein
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 20551911
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1020948
landingPage: http://www.iedb.org/assay/1797749
type:
Literature
publicationVenue:
Mol Ther
dates:
2010
study type: b cell assays
subject species: Homo sapiens
fullName:
Deborah A Ryan
Michael A Mastrangelo
Wade C Narrow
Mark A Sullivan
Howard J Federoff
William J Bowers
method:
in vivo assay
name:
Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.
description:
Mice receiving the epitope-specific mAb harbored lower levels of insoluble Abeta and hyperphosphorylated tau, and exhibited improved cognitive function as measured by the Morris Water Maze (MWM) spatial memory task.

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