Fab antibodies capable of blocking T cells by competitive binding have the identical specificity but a higher affinity to the MHC-peptide-complex than the T cell receptor.

Title:

Fab antibodies capable of blocking T cells by competitive binding have the identical specificity but a higher affinity to the MHC-peptide-complex than the T cell receptor.

Dataset

identifier:	1802321
description:	epitope description:RLQGISPKI antigen name:Protein SSX2 host organism:Homo sapiens antibody name:Fab-VIIIE1
aggregation:	instance of dataset
availability:	available
primaryPublications:	19524620

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1016506
landingPage:	http://www.iedb.org/assay/1802321

Publication

type:	Literature
publicationVenue:	Immunol Lett
dates:	2009

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Frank Neumann Christine Sturm Martin Hü lsmeyer Nina Dauth Philippe Guillaume Immanuel F Luescher Michael Pfreundschuh Gerhard Held

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	Fab antibodies capable of blocking T cells by competitive binding have the identical specificity but a higher affinity to the MHC-peptide-complex than the T cell receptor.
description:	The epitope sequence was from the cited reference: Held G et al. 2008. Int J Cancer, 123: 1841-7. [PMID: 18688854].

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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