Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1019849 |
| landingPage: |
http://www.iedb.org/assay/1800751 |
| type: |
Literature
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| publicationVenue: |
J Exp Med
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| dates: |
1974
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| study type: | b cell assays |
| subject species: |
| fullName: |
H Mossmann
M Meyer-Delius
U Vortisch
B Kickhö
fen
D K Hammer
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| method: |
in vivo skin test
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| name: |
Experimental studies on the bridging hypothesis of anaphylaxis: haptenic determinants required to elicit immediate-type reactions in calf skin by separate or concurrent sensitization with reagins of different specificity.
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| description: |
The reaginic (IgE) activity of the antisera was analyzed by a passive transfer test (Prausnitz-Kustner reaction). The early primary antibody response was low, and the late primary antibody and secondary antibody responses were modestly increased. The response to colostral whey after secondary challenge was ten times higher than that to serum. Bivalent DNP-ABA with noncross-reactive haptenic groups did not elicit a response from colostrum antibody, demonstrating the need for cross-linking of adjacent IgE molecules.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
