The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.

Title:

The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.

Dataset

identifier:	1801429
description:	epitope description:S396, S404 + PHOS(S396, S404) antigen name:Other Homo sapiens (human) protein host organism:Mus musculus antibody name:PHF-1
aggregation:	instance of dataset
availability:	available
primaryPublications:	20550628

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1020945
landingPage:	http://www.iedb.org/assay/1801429

Publication

type:	Literature
publicationVenue:	J Neurochem
dates:	2010

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Johanne Bertrand Patrick Sé né chal Mathieu Zummo-Soucy Vanessa Plouffe Nicole Leclerc

Data Type

method:	western blot

Study

name:	The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.
description:	The epitope-specific mAb staining was more intense in neurons over-expressing GFP-htau (human tau) than in non-transfected neurons indicating that transfected human tau was phosphorylated at these phospho-epitopes.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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