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Title: A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody ameliorates spontaneous and induced lupus manifestations in correlation with cytokine immunomodulation.
identifier: 1801545
description:
epitope description:GYYWSWIRQPPGKGEEWIG
antigen name:Other Homo sapiens (human) protein
host organism:Mus musculus BALB/c
aggregation:
instance of dataset
availability:
available
primaryPublications: 15622442
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1007076
landingPage: http://www.iedb.org/assay/1801545
type:
Literature
publicationVenue:
J Clin Immunol
dates:
2004
study type: b cell assays
subject species: Homo sapiens
fullName:
Dror Luger
Molly Dayan
Heidy Zinger
Jian-Ping Liu
Edna Mozes
method:
in vivo assay
name:
A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody ameliorates spontaneous and induced lupus manifestations in correlation with cytokine immunomodulation.
description:
The peptide was based on the complementarity determining region (CDR) 1 of the human anti-DNA monoclonal antibody that bears the 16/6Id.
Treatment with the epitope at any dose did not induce tolerance to human mAb 16/6Id, as measured by Ab titer.

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