Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel diseases.

Title:

Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel diseases.

identifier:	1802652
description:	epitope description:2,4-dinitrophenyl group host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	20505143

study type:	b cell assays
subject species:

fullName:	Anneke Rijnierse Frank A Redegeld Bart R Blokhuis Maurice W Van der Heijden Anje A Te Velde Inge Pronk Daniel W Hommes Frans P Nijkamp Andries S Koster Aletta D Kraneveld

method:	in vivo assay

name:	Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel diseases.
description:	Mice that received an intrarectal challenge of DNSB had increased disease symptoms including colonic tissue damage and increased mast cells, as well as an increase kappa Ig light chain in the spleen. It also leads to increase in TNF alpha in the colon.

name:	iedb
homePage:	http://www.iedb.org

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