Low concentrations of anti-Abeta antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology.

Title:

Low concentrations of anti-Abeta antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology.

Dataset

identifier:	1803582
description:	epitope description:DAEFRHDSGYE antigen name:Amyloid beta A4 protein host organism:Mus musculus C57BL/6 x SJL
aggregation:	instance of dataset
availability:	available
primaryPublications:	20528468

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1021109
landingPage:	http://www.iedb.org/assay/1803582

Publication

type:	Literature
publicationVenue:	Hum Gene Ther
dates:	2010

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Nina Movsesyan Hayk Davtyan Mikayel Mkrtichyan Irina Petrushina Tigran Tiraturyan Ted Ross Michael G Agadjanyan Anahit Ghochikyan David H Cribbs

Data Type

method:	in vivo assay

Study

name:	Low concentrations of anti-Abeta antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology.
description:	Biochemical analysis of brain tissues revealed no changes in soluble and insoluble Aß40 and Aß42 levels in both immunized and non-immunized groups of Tg2576 mice.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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